p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding.

@article{Liu2001p53PA,
  title={p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding.},
  author={Yunlong Liu and Molly Kulesz-Martin},
  journal={Carcinogenesis},
  year={2001},
  volume={22 6},
  pages={
          851-60
        }
}
Our environment contains physical, chemical and pathological agents that challenge the integrity of our DNA. In addition to DNA repair, higher multicellular organisms have evolved multiple pathways of response to damage including programmed cell death-apoptosis. The p53 protein appears to sense multiple types of DNA damage and coordinate with multiple options for cellular response. The p53 protein activities depend upon its DNA binding. Specific p53 protein post-translational modifications are… Expand
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