p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer

@article{Yamashita2006p53PA,
  title={p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer},
  author={Hiroko Yamashita and Tatsuya Toyama and Mariko Nishio and Y Ando and Maho Hamaguchi and Zhenhuan Zhang and Shunzo Kobayashi and Yoshitaka Fujii and Hirotaka Iwase},
  journal={Breast Cancer Research},
  year={2006},
  volume={8},
  pages={R48 - R48}
}
Endocrine therapy is the most important treatment option for women with hormone receptor-positive breast cancer. The potential mechanisms for endocrine resistance involve estrogen receptor (ER)-coregulatory proteins and cross-talk between ER and other growth factor-signaling networks. However, the factors and pathways responsible for endocrine resistance are still poorly identified. The expression of HER2, p53, and Ki67 was examined by immunohistochemistry in primary breast tumour specimens… CONTINUE READING
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