p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1


Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. Secondary malignant GCTB is rare, occurring in less than 2 % of GCTB cases. Mechanisms of malignant transformation of GCTB remain unclear. We examined 43 cases of GCTB (38 conventional cases, two lung implantation cases, and three secondary malignant cases) for p53 gene… (More)
DOI: 10.1007/s00428-013-1435-z

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