p53 mutations in classic and pleomorphic invasive lobular carcinoma of the breast

Abstract

p53 is a tumor suppressor that is frequently mutated in human cancers. Although alterations in p53 are common in breast cancer, few studies have specifically investigated TP53 mutations in the breast cancer subtype invasive lobular carcinoma (ILC). Recently reported conditional mouse models have indicated that functional p53 inactivation may play a role in… (More)
DOI: 10.1007/s13402-012-0071-y

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