p53 mutations have no additional prognostic value over stage in bladder cancer.

@article{Vet1994p53MH,
  title={p53 mutations have no additional prognostic value over stage in bladder cancer.},
  author={Jacqueline A. M. Vet and Pierre Paul Bringuier and Pino J. Poddighe and Herbert F. M. Karthaus and Frans M. J. Debruyne and Jack A Schalken},
  journal={British Journal of Cancer},
  year={1994},
  volume={70},
  pages={496 - 500}
}
Evidence is accumulating that the tumour-suppressor gene p53 is involved in the development of bladder cancer. Therefore we studied p53 mutations in 47 bladder cancers obtained from 45 patients using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. Eight out of 24 invasive tumours appeared to have a p53 mutation, while no p53 mutations were found in the superficial tumours. All the p53 mutations were found in grade 3 tumours. The tumours with altered p53… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from the p 53 in malignant astrocytomas

  • A. SAXENA, T. CLARK.W.G..ROBERTSON.J., B. IKEJIRI, E. H. OLD-FIELD, I. U. ALI
  • Cancer Res .
  • 1992
1 Excerpt

Similar Papers

Loading similar papers…