p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.

@article{Scorsone1992p53MC,
  title={p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.},
  author={K A Scorsone and Yanning Zhang Zhi-Hua Zhou and Janet S Butel and Betty L. Slagle},
  journal={Cancer research},
  year={1992},
  volume={52 6},
  pages={1635-8}
}
DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53, whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that… CONTINUE READING

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