p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.

  title={p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.},
  author={M D'errico and Angelo Salvatore Calcagnile and Rosamaria Corona and M Fucci and Giorgio Annessi and Giannandrea Baliva and Maria Elena Tosti and Paolo Pasquini and Eugenia Dogliotti},
  journal={Cancer research},
  volume={57 4},
Tumor DNA from 45 primary basal cell carcinoma (BCC) biopsies was screened for p53 gene mutations, chromosome 9 allele loss, and microsatellite instability. p53 mutation frequency increased significantly as a function of the age at BCC onset ranging from 6% (1/16) in early BCC (before age 40 years) to 35% (10/29) in late BCC. All p53 mutations found implicated sunlight as the mutagen. Chromosome 9 instability (allele loss or microsatellite instability) was detected at high frequency (38… CONTINUE READING


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