p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.

@article{Derrico1997p53MA,
  title={p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.},
  author={M D'errico and Angelo Salvatore Calcagnile and Rosamaria Corona and M Fucci and Giorgio Annessi and Giannandrea Baliva and Maria Elena Tosti and Paolo Pasquini and Eugenia Dogliotti},
  journal={Cancer research},
  year={1997},
  volume={57 4},
  pages={747-52}
}
Tumor DNA from 45 primary basal cell carcinoma (BCC) biopsies was screened for p53 gene mutations, chromosome 9 allele loss, and microsatellite instability. p53 mutation frequency increased significantly as a function of the age at BCC onset ranging from 6% (1/16) in early BCC (before age 40 years) to 35% (10/29) in late BCC. All p53 mutations found implicated sunlight as the mutagen. Chromosome 9 instability (allele loss or microsatellite instability) was detected at high frequency (38… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

A cell cycleregulator potentiallyinvolvedin genesisof manytumortypes

  • A. Kamb, N. A. Gruis, +7 authors M. H. andSkolnick
  • Nat . Genet .
  • 1996

A further assessmentof factorsinfluencingmeasurementsof thioguanineresistantmutantfre quency in circulating T - lymphocytes

  • J. Cole, M. H. L. Green, E. James.S., L. Henderson, H. Cole
  • Ann . 1 st . Super . Sanita
  • 1996

Crystal structure of a p 53 tumor suppressorDNAcomplex : understandingtumorigenic mutations

  • Y. Cho, S. Gonna, P. D. Jeffrey, N. P. Pavletich
  • NucleicAcids Res .
  • 1996

High frequency of loss of heterozygosityin actirnckeratoses , a usually benign disease

  • I. Rebman, A. G. Quinn, E. Healy, J. L. Rees
  • Proc . Ned . Aced . Sci . USA
  • 1996

Does intermittent sun exposurecausebasalcell carcinoma ? A casecontrolstudyin WesternAustralia

  • A. Kricker, B. K. Armstrong, R. EnglishD., P. J. Heenan
  • mt . J . Cancer
  • 1995

Similar Papers

Loading similar papers…