p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

@article{Lehman1991p53MR,
  title={p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.},
  author={Teresa A. Lehman and William P. Bennett and Robert A. Metcalf and Judith A. Welsh and J{\"u}rgen Ecker and Rama V. Modali and Susanne Ullrich and Joseph W. Romano and Ettore Appella and Joseph R Testa},
  journal={Cancer research},
  year={1991},
  volume={51 15},
  pages={4090-6}
}
The p53 tumor suppressor gene is frequently mutated and the K-ras oncogene is occasionally mutated in primary specimens of human lung carcinomas. These mutated genes also cooperate in the immortalization and neoplastic transformation of rodent cells. To determine whether these mutations are necessary for maintenance of the immortalized and/or neoplastically transformed states of human bronchial epithelial cells, the p53 gene and regions of the ras (K-, H-, and N-) genes were sequenced in nine… CONTINUE READING
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