p53 mutation pattern in hepatocellular carcinoma in workers exposed to vinyl chloride.

@article{Weihrauch2000p53MP,
  title={p53 mutation pattern in hepatocellular carcinoma in workers exposed to vinyl chloride.},
  author={Markus Weihrauch and G. Lehnert and Ferdinand Koeckerling and Christian Wittekind and Andrea Tannapfel},
  journal={Cancer},
  year={2000},
  volume={88 5},
  pages={1030-6}
}
BACKGROUND Vinyl chloride (VC) is a known animal and human carcinogen that is associated with liver angiosarcoma and most likely also with hepatocellular carcinoma (HCC) in humans. METHODS The authors examined the presence of p53 gene mutations in 18 HCC specimens from patients with known exposure to VC (median, 8883 parts per million-years; median duration, 245 months). In all cases, other risk factors for the development of HCC (hepatitis B virus and hepatitis C virus infections, alcohol… CONTINUE READING

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