p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma.

Abstract

We examined the relationship between p53 mutation, murine double minute 2 (MDM2) gene amplification, and human papillomavirus (HPV) infection in 72 esophageal squamous cell carcinomas. We identified p53 mutations in 29 tumors (40.3%) by PCR-single-strand conformation polymorphism analysis and direct sequencing. Amplification of the MDM2 gene was detected by… (More)

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Cite this paper

@article{Shibagaki1995p53MM, title={p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma.}, author={Ichio Shibagaki and H. Tanaka and Yutaka Shimada and Takashi Wagata and Mituo Ikenaga and Masahiro Imamura and Kanji Ishizaki}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={1995}, volume={1 7}, pages={769-73} }