p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry.

@article{Eckardstein1997p53MA,
  title={p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry.},
  author={Kajetan L von Eckardstein and Heinz Gries and E. Bolik and J{\'o}rge Cerv{\'o}s-Navarro and I N Tschairkin and Stephan Patt},
  journal={Histology and histopathology},
  year={1997},
  volume={12 3},
  pages={
          611-6
        }
}
Alterations of the p53 protein, which is a 53 kD phosphoprotein and gene product of the p53 gene, has been found to play a major role in the genesis of a variety of human malignancies including tumors of the central nervous system. We investigated 50 tumor specimens from primary central nervous system neoplasms. Tissue samples were screened for mutations by the single-strand conformation polymorphism method and detected mutations were sequenced. All tissue specimens were stained… CONTINUE READING

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