p53 mutant mice that display early ageing-associated phenotypes

  title={p53 mutant mice that display early ageing-associated phenotypes},
  author={S. D. Tyner and S. Venkatachalam and J. Choi and S. Jones and Nader Ghebranious and Herbert Igelmann and X. Lu and Gabrielle Soron and B. Cooper and C. Brayton and S. Park and T. Thompson and G. Karsenty and A. Bradley and L. Donehower},
  • S. D. Tyner, S. Venkatachalam, +12 authors L. Donehower
  • Published 2002
  • Medicine, Biology
  • Nature
  • The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous… CONTINUE READING
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