p53 modulation of TFIIH–associated nucleotide excision repair activity

  title={p53 modulation of TFIIH–associated nucleotide excision repair activity},
  author={X. Wang and H. Yeh and L. Schäffer and R. Roy and V. Moncollin and J.-M. Egly and Z. Wang and E. C. Friedberg and M. Evans and B. G. Taffe and V. A. Bohr and G. Weeda and J.H.J. Hoeijmakers and K. Forrester and C. C. Harris},
  journal={Nature Genetics},
  • X. Wang, H. Yeh, +12 authors C.C. Harris
  • Published 1995
  • Biology, Medicine
  • Nature Genetics
  • p53 has pleiotropic functions including control of genomic plasticity and integrity. Here we report that p53 can bind to several transcription factor IIH–associated factors, including transcription–repair factors, XPD (Rad3) and XPB, as well as CSB involved in strand–specific DNA repair, via its C–terminal domain. We also found that wild–type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities. Moreover, repair of UV–induced dimers is slower in Li–Fraumeni syndrome… CONTINUE READING
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