p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.

@article{Soberanes2006p53MP,
  title={p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.},
  author={Saul Soberanes and Vijayalakshmi Panduri and G{\"o}khan M Mutlu and A. Ghio and G R Scott Bundinger and David W. Kamp},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 11},
  pages={1229-38}
}
RATIONALE Exposure to particulate matter (PM) causes lung cancer by mechanisms that are unknown, but p53 dysfunction is implicated. OBJECTIVE We determined whether p53 is required for PM-induced apoptosis in both human and rodent alveolar type (AT) 2 cells. METHODS A well-characterized form of urban PM was used to determine whether it induces mitochondrial dysfunction (mitochondrial membrane potential change [DeltaPsi m] and caspase-9 activation), p53 protein and mRNA expression, and… CONTINUE READING