p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.

@article{Faniello2008p53mediatedDO,
  title={p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.},
  author={Maria Concetta Faniello and Maddalena Di Sanzo and Barbara Quaresima and Francesco Baudi and Valentina Di Caro and Giovanni Cuda and Giovanni Morrone and Giannino Del Sal and Giovanni Spinelli and Salvatore Venuta and Francesco Costanzo},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 10},
  pages={
          2110-9
        }
}
The tumor suppressor protein p53 triggers many of the cellular responses to DNA damage by regulating the transcription of a series of downstream target genes. p53 acts on the promoter of the target genes by interacting with the trimeric transcription factor NF-Y. H ferritin promoter activity is tightly dependent on a multiprotein complex called Bbf; on this complex NF-Y plays a major role. The aim of this work was to study the modulation of H ferritin expression levels by p53. CAT reporter… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor.

  • The Journal of biological chemistry
  • 1999
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A new technique for the assay of infectivity of human adenovirus 5 DNA

C. Imbriano, A. Gurtner, +3 authors M. Gostissa
  • Virology
  • 2005
VIEW 3 EXCERPTS