p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.

@article{Wu2004p53mediatedCC,
  title={p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.},
  author={Zhen Wu and Lijun Wu and Linhao Li and Shin-ichi Tashiro and Satoshi Onodera and Takashi Ikejima},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={94 2},
  pages={166-76}
}
Natural products regulate cell growth in response to oncogene activation that induces cell cycle arrest and apoptosis in tumor cell lines. We investigated the mechanisms of caspase activation in human malignant melanoma, A375-S2 cells, by the natural product shikonin, which was isolated from the plant Lithospermum erythrorhizon SIEB. et ZUCC. Shikonin inhibited cell growth in a time- and dose-dependent manner, which might be mediated through up-regulation of p53 and down-regulation of cyclin… CONTINUE READING

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