p53 mRNA controls p53 activity by managing Mdm2 functions

@article{Candeias2008p53MC,
  title={p53 mRNA controls p53 activity by managing Mdm2 functions},
  author={Marco Marques Candeias and Laurence Malbert-Colas and Darren J. Powell and Chrysoula Daskalogianni and Magdalena M. Maslon and Nadia Naski and Karima Bourougaa and Fabien Calvo and Robin F{\aa}hraeus},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1098-1105}
}
The E3 ubiquitin ligase Mdm2 is a focal regulator of p53 tumour suppressor activity. It binds p53, promoting its polyubiquitination and degradation, and also controls p53 synthesis. However, it is not known how this dual function of Mdm2 on p53 synthesis and degradation is achieved. Here we show that the p53 mRNA region encoding the Mdm2-binding site interacts directly with the RING domain of Mdm2. This impairs the E3 ligase activity of Mdm2 and promotes p53 mRNA translation. We also show that… 

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...

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