p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.

  title={p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.},
  author={Zhen Zhao and Johannes Zuber and Ernesto D{\'i}az-Flores and Laura Lintault and Scott Kogan and Kevin F Shannon and Scott W Lowe},
  journal={Genes & development},
  volume={24 13},
The p53 tumor suppressor limits proliferation in response to cellular stress through several mechanisms. Here, we test whether the recently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute myeloid leukemia (AML), an aggressive cancer in which p53 mutations are associated with drug resistance and adverse outcome. Our approach combined mosaic mouse models, Cre-lox technology, and in vivo RNAi to disable p53 and simultaneously activate endogenous Kras(G12D… CONTINUE READING
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