p53 lesions in leukemic transformation.

  title={p53 lesions in leukemic transformation.},
  author={Ashot S Harutyunyan and Thorsten Klampfl and Mario Cazzola and Robert Kralovics},
  journal={The New England journal of medicine},
  volume={364 5},
To the Editor: Myeloproliferative neoplasms have an inherent tendency toward leukemic transformation. The genetic mechanisms of transformation remain largely unknown. We analyzed biopsy specimens of myeloproliferative neoplastic tissue from 330 patients for chromosomal aberrations associated with leukemic transformation (the analysis was performed with the use of Genome-Wide Human SNP [single-nucleotide polymorphism] Array, Affymetrix). Of those patients, 308 had chronic-phase… CONTINUE READING


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