p53 is positively regulated by miR-542-3p.

  title={p53 is positively regulated by miR-542-3p.},
  author={Yemin Wang and Jen-Wei Huang and Maria Castell{\`a} and David G. Huntsman and Toshiyasu Taniguchi},
  journal={Cancer research},
  volume={74 12},
The tumor suppressor p53 and miRNAs are linked through a complex network. Several miRNAs modulate p53 expression, while p53 regulates the transcription and/or biogenesis of several other miRNAs. Here, we report the development of a cell-based assay used with a library of human miRNA mimics in a high-throughput screen for miRNAs that modulate p53 expression. Overexpression of miRNA (miR)-542-3p in cancer cells elevated p53 expression, stimulated the expression of p53 targets, and inhibited cell… CONTINUE READING


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Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits Cancer Res

  • DryginD, LinA, J Bliesath, HoCB, O'BrienSE, C Proffitt
  • Cancer Research 3226 Wang et al. on April
  • 2014
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