p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

@article{Tovy2017p53IE,
  title={p53 is essential for DNA methylation homeostasis in na{\"i}ve embryonic stem cells, and its loss promotes clonal heterogeneity.},
  author={Ayala Tovy and Adam Spiro and Ryan L McCarthy and Zohar Shipony and Yael Aylon and Kendra L Allton and Elena Ainbinder and Noa Furth and Amos Tanay and Michelle Craig Barton and Moshe Oren},
  journal={Genes & development},
  year={2017},
  volume={31 10},
  pages={
          959-972
        }
}
DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in naïve mouse ESCs (mESCs), p53 restricts the expression of the de novo DNA methyltransferases Dnmt3a and Dnmt3b while up-regulating Tet1 and Tet2, which promote DNA demethylation… CONTINUE READING
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