p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose.

@article{Sinthupibulyakit2009p53IA,
  title={p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose.},
  author={Chompunoot Sinthupibulyakit and Kristopher Ray Grimes and F E Domann and Yong Biao Xu and Fang Fang and Wanida Ittarat and Daret K. St. Clair and William H. St. Clair},
  journal={International journal of oncology},
  year={2009},
  volume={35 3},
  pages={
          609-15
        }
}
Metabolic change in cancer cells by preferential production of energy through glycolysis is a well-documented characteristic of cancer. However, whether inhibition of glycolysis will enhance the efficacy of radiation therapy is a matter of debate. In this study which uses lung cancer as the model, we demonstrate that the improvement of radiotherapy by 2-deoxy-D-glucose (2DG) is p53-dependent. Based on clonogenic survival data, we show that p53-deficient lung cancer cells (H358) are more… CONTINUE READING
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