p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis.

@article{Martin2000p53IA,
  title={p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis.},
  author={Lee J. Martin},
  journal={Neurobiology of disease},
  year={2000},
  volume={7 6 Pt B},
  pages={613-22}
}
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a form of apoptosis, but the mechanisms for this neuronal cell death are not known. We evaluated whether motor neuron degeneration in ALS is associated with changes in the levels and function of the apoptosis regulating protein p53. The protein levels and localizations of p53 are abnormal in ALS. By immunoblotting, p53 is elevated in the nuclear compartment of selectively vulnerable CNS regions in individuals with ALS compared… CONTINUE READING
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