p53 involvement in the pathogenesis of fatty liver disease.

  title={p53 involvement in the pathogenesis of fatty liver disease.},
  author={Naoya Yahagi and Hitoshi Shimano and Takashi Matsuzaka and Motohiro Sekiya and Yuho Najima and Sachiko Okazaki and Hiroaki Okazaki and Yoshiaki Tamura and Yoko Iizuka and Noriyuki Inoue and Yoshimi Nakagawa and Yoshinori Takeuchi and Ken Ohashi and Kenji Harada and Takanari Gotoda and Ryozo Nagai and Takashi Kadowaki and Shun Ishibashi and Jun-ichi Osuga and Nobuhiro Yamada},
  journal={The Journal of biological chemistry},
  volume={279 20},
Obesity is a major health problem in industrialized societies, and fatty liver disease (hepatic steatosis) is common in obese individuals. Oxidative stress originating from increased intracellular levels of fatty acids has been implicated as a cause of hepatocellular injury in steatosis, although the precise mechanisms remain to be elucidated. p53, widely known as a tumor suppressor, has been shown often to be activated in stressed cells, inducing cell cycle arrest or death. Here we demonstrate… CONTINUE READING