p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling.

Abstract

Tumor suppressor p53 has recently been reported to have numerous functions independent of tumorigenesis, including neuronal survival during ischemia. The mammalian target of rapamycin (mTOR) signaling pathway plays a central role in the regulation of metabolism, cell growth, development, and cell survival. Our recent work has demonstrated the… (More)
DOI: 10.1016/j.brainres.2015.02.009

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