p53 in head and neck cancer: Functional consequences and environmental implications of TP53 mutations

@inproceedings{Peltonen2010p53IH,
  title={p53 in head and neck cancer: Functional consequences and environmental implications of TP53 mutations},
  author={Jenni K Peltonen and Henni M Helppi and Paavo K P{\"a}{\"a}kk{\"o} and Taina Turpeenniemi-Hujanen and Kirsi H. V{\"a}h{\"a}kangas},
  booktitle={Head & neck oncology},
  year={2010}
}
BACKGROUND Although TP53 mutations in human tumours generally have been extensively studied, the significance of p53 in the aetiology of head and neck cancers is still incompletely characterized. In recent years, considerable interest has been focused on mutant forms of p53, the abnormal protein product of TP53 alleles with missense mutation that often accumulate in cancer cells. METHODS We compared the nature of TP53 mutations in primary 46 head and neck squamous cell carcinomas (HNSCC… CONTINUE READING
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