p53 immunoexpression in non-malignant oral mucosa adjacent to oral squamous cell carcinoma: potential consequences for clinical management.

@article{Cruz2000p53II,
  title={p53 immunoexpression in non-malignant oral mucosa adjacent to oral squamous cell carcinoma: potential consequences for clinical management.},
  author={Isabel B. Cruz and Chris J L M Meijer and Peter J. F. Snijders and Gordon B J Snow and Jan M. M. Walboomers and I Van der Waal},
  journal={The Journal of pathology},
  year={2000},
  volume={191 2},
  pages={132-7}
}
p53 is a tumour suppressor gene encoding a protein whose function is impaired in a very large proportion of human cancers. The objectives of this study were to determine the natural history of p53 alterations during stages of oral carcinogenesis, by comparing p53 immunoexpression in oral squamous cell carcinomas (OSCCs), their non-malignant adjacent mucosa, and respective metastases; and to define the potential practical consequences for clinical management of p53 staining in the non-malignant… CONTINUE READING
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