p53 genotypes and haplotypes associated with risk of breast cancer.

  title={p53 genotypes and haplotypes associated with risk of breast cancer.},
  author={Nur Buyru and Julide Altinisik and Semra Demokan and Nejat Dalay},
  journal={Cancer detection and prevention},
  volume={31 3},
INTRODUCTION The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms… CONTINUE READING
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