p53 gene transfer to the injured rat carotid artery decreases neointimal formation.

@article{Scheinman1999p53GT,
  title={p53 gene transfer to the injured rat carotid artery decreases neointimal formation.},
  author={Marcel Scheinman and Enrico Ascher and Gabriel S Levi and Anil J Hingorani and Djamshid Shirazian and Pankaj Seth},
  journal={Journal of vascular surgery},
  year={1999},
  volume={29 2},
  pages={360-9}
}
PURPOSE We studied the effect of adenovirus-mediated p53 gene transfer on the injured rat carotid artery to determine its ability to decrease the formation of neointima. METHODS In vivo gene transfer was used in isolated segments of balloon-injured rat carotid arteries. Genetically modified adenovirus containing the gene encoding for wild-type p53 (AdWTp53) was applied in three concentrations: 8 x 10(10), 1.6 x 10(10), and 8 x 10(9) pfu/mL. Control rats received either adenovirus null (AdNull… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…