p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

  title={p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.},
  author={Stacey J. Baker and Ann C. Preisinger and John Milburn Jessup and Christos Paraskeva and Sanford D Markowitz and James K. V. Willson and Shea Hamilton and Bert Vogelstein},
  journal={Cancer research},
  volume={50 23},
Coordinate loss of one copy of the p53 gene and mutation of the remaining copy occur in colorectal carcinomas and in many other human malignancies. However, the prevalence of p53 gene mutations in carcinomas which maintain both parental copies of p53 has not previously been evaluated. Moreover, it is not known whether p53 gene mutations are limited to malignant tumors or whether they can also occur in benign neoplasms. To answer these questions, a total of 58 colorectal tumors have been… CONTINUE READING
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