p53 gene mutations in soft-tissue sarcomas-correlations with p53 immunohistochemistry and DNA ploidy

@article{SchneiderStock1997p53GM,
  title={p53 gene mutations in soft-tissue sarcomas-correlations with p53 immunohistochemistry and DNA ploidy},
  author={Regine Schneider-Stock and Kathrin Radig and Yoshinao Oda and Walter Mellin and Janusz Ryś and Aleksander Niezabitowski and Albert Roessner},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1997},
  volume={123},
  pages={211-218}
}
The significance ofp53 mutations in a group of 67 soft-tissue tumors was examined using single-strand conformation polymorphism and direct sequencing analysis. Molecular findings were correlated with immunohistochemical detection of thep53 protein and DNA ploidy status. Mutations of thep53 gene were detected in 13 (19.5%) out of 67 cases of soft-tissue tumors. Only there were localized outside the conservative regions of thep53 gene. Six mutations were described for the first time in these… CONTINUE READING

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