p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients.

@article{Zhang1998p53GM,
  title={p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients.},
  author={Run J Zhang and Satori Takahashi and Satoshi Orita and Akira Yoshida and Haruhiko Maruyama and Tomoyuki Shirai and Nagayoshi Ohta},
  journal={Cancer letters},
  year={1998},
  volume={131 2},
  pages={
          215-21
        }
}
Mutations in p53 tumor suppressor gene were examined in 44 Chinese patients with rectal cancer, including 22 cases with advanced schistosomiasis japonica and 22 cases without schistosomiasis. In schistosomal rectal cancer (SRC), 13 mutations were found in 10 cases, which included 11 base-pair substitutions and two deletions. Of 11 base substitutions, nine were transitions and two were transversions and seven of them were located at CpG dinucleotides. In non-schistosomal rectal cancer (NSRC), 13… CONTINUE READING

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