p53 gene mutations in human epithelial skin cancers.

  title={p53 gene mutations in human epithelial skin cancers.},
  author={J P Mol{\`e}s and C Moyret and Bernard Guillot and P. Jeanteur and J J Guilhou and Charles Theillet and Nicole Basset-S{\'e}guin},
  volume={8 3},
In the present study we analysed 38 epithelial skin cancers, 19 basal cell carcinomas (BCCs), 13 squamous cell carcinomas (SCCs) and six Bowen diseases (BwDs), using a combination of polymerase chain reaction (PCR) and single-stranded conformation polymorphism (SSCP) techniques for the presence of p53 and RAS gene mutations. Whereas 48% (9/19) of the BCCs tested presented a mutated p53 gene, the frequency was lower (15%, 2/13) in our series of SCCs and negative in the BwDs. Nine of the 11… CONTINUE READING


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