p53 gene mutations in gastric adenomas.

  title={p53 gene mutations in gastric adenomas.},
  author={Hiroko Tohdo and Hiroshi Yokozaki and Ken Haruma and Goro Kajiyama and Eiichi Tahara},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  volume={63 3},
p53 gene alterations in ten gastric adenomas and one carcinoma arising in an adenoma were analyzed by deoxynucleotide sequencing. Three (30%) of the ten gastric adenomas had p53 gene mutations, one adenoma showing a frameshift mutation and two others showing silent mutations. In addition, two missense mutations occurred in the carcinoma arising in an adenoma. Histologically, the adenomas containing silent mutations revealed moderate dysplasia. Immunoreactivity to p53 protein was also examined… CONTINUE READING
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