p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence.

@article{Hasegawa1995p53GM,
  title={p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence.},
  author={Hitoshi Hasegawa and Masakazu Ueda and Kiyoshi Furukawa and Masatoshi Watanabe and Tatsuo Teramoto and Makio Mukai and Masaki Kitajima},
  journal={International journal of cancer},
  year={1995},
  volume={64 1},
  pages={47-51}
}
p53 gene mutations in early and advanced colorectal cancer were detected by PCR-SSCP analysis. Early colorectal cancer was classified into de novo cancer and polyp-forming cancer, respectively, according to morphology and presence of adenomatous components. A total of 94 paraffin-embedded tissue specimens from patients with colorectal cancer were analysed. p53 gene mutations were detected in 40.0% (12/30) of de novo cancer, 36.7% (11/30) of polyp-forming cancer, and 44% (15/34) of advanced… CONTINUE READING

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