p53 gene mutations and p21 protein expression induced independently of p53, by TGF-beta and gamma-rays in squamous cell carcinoma cells.

@article{Yoneda1999p53GM,
  title={p53 gene mutations and p21 protein expression induced independently of p53, by TGF-beta and gamma-rays in squamous cell carcinoma cells.},
  author={Kazunori Yoneda and Takashi Yokoyama and Tetsuya Yamamoto and T Hatabe and Tokio Osaki},
  journal={European journal of cancer},
  year={1999},
  volume={35 2},
  pages={278-83}
}
p53 gene mutation and the influence of TGF-beta and gamma-rays on p21 promoter activity, p21 mRNA and protein expression were investigated in nine cell lines (OSC-1 to -9) established from metastatic squamous cell carcinomas (SCC) of the cervical lymph nodes. The direct DNA sequence analysis of exons 2 to 11 of the p53 gene revealed 16 point mutations in all cell lines, but neither deletions nor additions were observed. TGF-beta upregulated p21 promoter activity by approximately 2-fold of the… CONTINUE READING

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