p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

@article{SouzaPinto2004p53FI,
  title={p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria},
  author={Nadja C. de Souza-Pinto and Curtis C. Harris and Vilhelm A. Bohr},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={6559-6568}
}
The tumor suppressor p53 protein stimulates nuclear base excision repair (BER) in vitro. In response to certain cellular stresses, p53 translocates to mitochondria, where it can trigger an apoptotic response. However, a potential role for p53 in modulating mitochondrial DNA repair has not yet been examined. In this study, we show that p53 also modulates mitochondrial BER. Uracil-initiated BER incorporation, which measures flux through the entire BER pathway, was lower in mitochondrial extracts… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-6 of 6 references

Mutat

  • AR Evans, M Limp-Foster, MR.. Kelley
  • Res., 461, 83–108.
  • 2000
Highly Influential
3 Excerpts

Mol

  • M Mihara, S Erster, +4 authors UM. Moll
  • Cell, 11, 577–590.
  • 2003

Proc

  • MJ Longley, R Prasad, DK Srivastava, SH Wilson, WC. Copeland
  • Natl. Acad. Sci. USA, 95, 12244–12248.
  • 1998
2 Excerpts

Biochem

  • T Taguchi, M Ogihara, T Maekawa, F Hanaoka, M. Tanno
  • Biophys. Res. Commun., 216, 715–722.
  • 1995

J

  • DM Wilson, M Takeshita, AP Grollman, B. Demple
  • Biol. Chem., 270, 16002–16007.
  • 1995

Nat

  • XW Wang, H Yeh, +7 authors BG. Taffe
  • Genet., 10, 188–195.
  • 1995

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