p53 expression and apoptosis in the lens after ultraviolet radiation exposure.

@article{Ayala2007p53EA,
  title={p53 expression and apoptosis in the lens after ultraviolet radiation exposure.},
  author={Marcelo Ayala and Hilja Strid and Ulrika Jacobsson and Per G. S{\"o}derberg},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 9},
  pages={4187-91}
}
PURPOSE To localize p53 protein and active caspase-3 in the albino rat lens and to compare p53 mRNA and active caspase-3 expression in ultraviolet radiation (UVR) 300 nm exposed lenses and their contralateral nonexposed controls. METHODS Ten Sprague-Dawley albino rats were unilaterally exposed to 8 kJ/m(2) UVR, and the contralateral eyes were left nonexposed. In total, four exposed lenses and their respective contralateral nonexposed lenses were analyzed by immunohistochemistry to localize… CONTINUE READING

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Investigative ophthalmology & visual science • 2000

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