p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

@inproceedings{Baudot2016p53DR,
  title={p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death},
  author={Alice D. Baudot and Diane Crighton and J O'prey and Joanna Somers and Pablo Sierra Gonzalez and Kevin M. Ryan},
  booktitle={Cell cycle},
  year={2016}
}
p53 is a central factor in tumor suppression as exemplified by its frequent loss in human cancer. p53 exerts its tumor suppressive effects in multiple ways, but the ability to invoke the eradication of damaged cells by programmed cell death is considered a key factor. The ways in which p53 promotes cell death can involve direct activation or engagement of the cell death machinery, or can be via indirect mechanisms, for example though regulation of ER stress and autophagy. We present here… CONTINUE READING
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