p53 determines multidrug sensitivity of childhood neuroblastoma.

@article{Xue2007p53DM,
  title={p53 determines multidrug sensitivity of childhood neuroblastoma.},
  author={Chengyuan Xue and Michelle Haber and Claudia L. Flemming and Glenn M. Marshall and Richard B. Lock and Karen L. Mackenzie and Katerina V Gurova and Murray D Norris and Andrei V. Gudkov},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={
          10351-60
        }
}
For pediatric cancers like neuroblastoma, the most common extracranial solid tumor of infancy, p53 mutations are rare at diagnosis, but may be acquired after chemotherapy, suggesting a potential role in drug resistance. Heavy metal-selected neuroblastoma cells were found to acquire an unusually broad multidrug resistance (MDR) phenotype but displayed no alterations in genes associated with "classic" MDR. These cells had acquired a mutant p53 gene, linking p53 to drug sensitivity in… CONTINUE READING
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