p53-dependent translational control of senescence and transformation via 4E-BPs.

@article{Petroulakis2009p53dependentTC,
  title={p53-dependent translational control of senescence and transformation via 4E-BPs.},
  author={Emmanuel Petroulakis and Armen Parsyan and Ryan J. O. Dowling and Olivier LeBacquer and Yvan Martineau and Michael A Bidinosti and O Larsson and Tommy Alain and Liwei Rong and Ya{\"e}l Mamane and Maril{\`e}ne Paquet and Luc Furic and Ivan Topisirovic and David Shahbazian and Mark Livingstone and Mauro Costa-Mattioli and Jose G Teodoro and Nahum Sonenberg},
  journal={Cancer cell},
  year={2009},
  volume={16 5},
  pages={439-46}
}
eIF4E, the mRNA 5' cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and senescence. 4E-BPs (eIF4E-binding proteins) inhibit eIF4E activity, and thereby act as suppressors of eIF4E-dependent pathways. Here, we show that tumorigenesis is increased in p53 knockout mice that lack 4E-BP1 and 4E-BP2. However, primary fibroblasts lacking 4E-BPs, but expressing p53, undergo premature senescence and resist oncogene… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Translation Control by p53

Cancers • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 41 references

expressed at growth arrest of mammalian cells

R. Schneider, N. Sonenberg
In Translational Control in Biology and Medicine, • 2007
View 6 Excerpts
Highly Influenced

Intrinsic tumour suppression

View 4 Excerpts
Highly Influenced

Phosphorylated 4E-BP1 is associated with poor survival in melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 2 Excerpts

Trans lational control of the innate immune response through IRF 7

R. Colina, M. Costa Mattioli, +8 authors Y.V
Nature 452, • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…