p53-dependent translational control of senescence and transformation via 4E-BPs.

  title={p53-dependent translational control of senescence and transformation via 4E-BPs.},
  author={Emmanuel Petroulakis and Armen Parsyan and Ryan J. O. Dowling and Olivier LeBacquer and Yvan Martineau and Michael A Bidinosti and O Larsson and Tommy Alain and Liwei Rong and Ya{\"e}l Mamane and Maril{\`e}ne Paquet and Luc Furic and Ivan Topisirovic and David Shahbazian and Mark Livingstone and Mauro Costa-Mattioli and Jose G Teodoro and Nahum Sonenberg},
  journal={Cancer cell},
  volume={16 5},
eIF4E, the mRNA 5' cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and senescence. 4E-BPs (eIF4E-binding proteins) inhibit eIF4E activity, and thereby act as suppressors of eIF4E-dependent pathways. Here, we show that tumorigenesis is increased in p53 knockout mice that lack 4E-BP1 and 4E-BP2. However, primary fibroblasts lacking 4E-BPs, but expressing p53, undergo premature senescence and resist oncogene… CONTINUE READING


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