p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss.

@article{Brosh2010p53dependentTR,
  title={p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss.},
  author={Ran Brosh and Rachel Sarig and Elad Bar Natan and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter},
  journal={FEBS letters},
  year={2010},
  volume={584 11},
  pages={2473-7}
}
The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during… CONTINUE READING