p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

@article{Pinho2011p53dependentRO,
  title={p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.},
  author={Andreia V. Pinho and Ilse Rooman and Francisco X Real},
  journal={Cell cycle},
  year={2011},
  volume={10 8},
  pages={1312-21}
}
Pancreatic acinar cells acquire in vitro a pancreatic progenitor phenotype associated with activation of p53, growth arrest and senescence. A similar program is also activated in chronic pancreatitis. To assess the mechanisms involved in this process, we cultured pancreatic acinar cells from wild-type, p53(-/-), p16(-/-) and p21(-/-) mice. Cultures from p53… CONTINUE READING