p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2

@article{Martel2006p53dependentIO,
  title={p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2},
  author={V{\'e}ronique Martel and Odile Filhol and Pierre Colas and Claude Cochet},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={7343-7353}
}
Based on the perturbation of its expression in human cancers and on its involvement in transformation and tumorigenesis, protein kinase CK2 has recently attracted attention as a potential therapeutic target. To assess the value of CK2 as a target for antiproliferative strategies, we have initiated a program aiming to develop inhibitors targeting specifically the regulatory CK2β subunit. Here, we use a two-hybrid approach to isolate from combinatorial libraries, peptide aptamers that… CONTINUE READING
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