p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells.

  title={p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells.},
  author={Toshio Ohtsubo and X. Henry Wang and Akihisa Takahashi and Ken Ohnishi and Hiromitsu Saito and Chang Won Song and Takeo Ohnishi},
  journal={Cancer research},
  volume={57 18},
The effects of an acidic condition (pH 6.5) on WAF1 gene expression and p53 accumulation was investigated in human glioblastoma cells with different p53 statuses. WAF1 and p53 accumulation after treatment in acidic conditions was observed in A-172 cells carrying the wild-type p53 gene but not in T98G cells carrying the mutant p53 gene. Northern blot analysis showed that WAF1 gene activation by acidic conditions only occurred in A-172 cells. Consistent with this, activation of the binding of p53… CONTINUE READING
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