p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A.

@article{Okamoto1996p53dependentAB,
  title={p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A.},
  author={Koji Okamoto and Craig Kamibayashi and Manuel Serrano and Carol Prives and Marc C. Mumby and David S. Beach},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 11},
  pages={6593-602}
}
We and others previously showed that cyclin G is a transcriptional target of the p53 tumor suppressor protein. However, cellular proteins which might form a complex with cyclin G have not yet been identified. To gain insight into the biological role of cyclin G, we used the yeast two-hybrid screen and isolated two mouse cDNAs encoding cyclin G-interacting proteins. Interestingly, both positive cDNAs encoded B' regulatory subunits of protein phosphatase 2A (PP2A). One clone encodes B'alpha… CONTINUE READING

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