p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

@article{Morgenbesser1994p53dependentAP,
  title={p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens},
  author={Sharon D. Morgenbesser and Bart O. Williams and Tyler 8 Jacks and Ronald A. Depinho},
  journal={Nature},
  year={1994},
  volume={371},
  pages={72-74}
}
THE retinoblastoma tumour-suppressor gene (RB) has been implicated in negative growth regulation, induction of differentiation, and inhibition of cellular transformation1. Homozygous inactivation of the Rb gene in the mouse leads to mid-gestational lethality with defects in erythropoiesis and neurogenesis2–4. Here we describe the effects of the Rb-deficient state on the development of the ocular lens. The regional compartmentalization of growth, differentiation and apoptosis in the developing… CONTINUE READING