p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

@article{Lowe1993p53dependentAM,
  title={p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.},
  author={Scott W Lowe and H. Earl Ruley and Tyler 8 Jacks and David Housman},
  journal={Cell},
  year={1993},
  volume={74 6},
  pages={957-67}
}
Although the primary cellular targets of many anticancer agents have been identified, less is known about the processes leading to the selective cell death of cancer cells or the molecular basis of drug resistance. p53-deficient mouse embryonic fibroblasts were used to examine systematically the requirement for p53 in cellular sensitivity and resistance to a diverse group of anticancer agents. These results demonstrate that an oncogene, specifically the adenovirus E1A gene, can sensitize… CONTINUE READING
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