p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress.

@article{Datta2002p53DA,
  title={p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress.},
  author={Kamal K. Datta and Preeti Babbar and Tapasya Srivastava and Subrata Sinha and Parthaprasad Chattopadhyay},
  journal={The international journal of biochemistry & cell biology},
  year={2002},
  volume={34 2},
  pages={148-57}
}
Generation of reactive oxygen species (ROS) is an important mode of action of many chemotherapeutic agents. Hydrogen peroxide (H(2)O(2)) is a model oxidant that has been used to study the response of cells to oxidative stress. The role of p53 in ROS induced cell death has not been consistent and has been shown to be cell type dependent. Study of cellular and molecular parameters and mechanisms involved in H(2)O(2) induced cell death in glioma cells will contribute to the understanding of… CONTINUE READING
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