p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

@article{Macleod1995p53dependentAI,
  title={p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.},
  author={Kay F. Macleod and Nicole A. Sherry and Gregory J Hannon and David S. Beach and Takashi Tokino and Kenneth W. Kinzler and Bert Vogelstein and Tim Jacks},
  journal={Genes & development},
  year={1995},
  volume={9 8},
  pages={935-44}
}
Expression of p21 has been shown to be up-regulated by the p53 tumor suppressor gene in vitro in response to DNA-damaging agents. However, p21 expression can be regulated independently of p53, and here we show that expression of p21 in various tissues during development and in the adult mouse occurs in the absence of p53 function. However, most tissues tested did require p53 for p21 induction following exposure of the whole animal to gamma irradiation. These results show that normal tissue… CONTINUE READING
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